a yap Search Results


hrp antibody all-in-one conjugation kit  (Vector Laboratories)
95
Vector Laboratories hrp antibody all-in-one conjugation kit
Hrp Antibody All In One Conjugation Kit, supplied by Vector Laboratories, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/hrp antibody all-in-one conjugation kit/product/Vector Laboratories
Average 95 stars, based on 1 article reviews
hrp antibody all-in-one conjugation kit - by Bioz Stars, 2026-02
95/100 stars
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flexitube sirna constructs for yap and mrtf-a  (Qiagen)
90
Qiagen flexitube sirna constructs for yap and mrtf-a
Flexitube Sirna Constructs For Yap And Mrtf A, supplied by Qiagen, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/flexitube sirna constructs for yap and mrtf-a/product/Qiagen
Average 90 stars, based on 1 article reviews
flexitube sirna constructs for yap and mrtf-a - by Bioz Stars, 2026-02
90/100 stars
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ihc analysis of yap, et a r, and et-1 protein expression  (Human Protein Atlas)
90
Human Protein Atlas ihc analysis of yap, et a r, and et-1 protein expression
Expression of <t>YAP</t> and ET-1/ET A R as a prognostic signature <t>in</t> <t>HG-SOC</t> patients. a , b Relative EDNRA (ET A R), CCNA , and CTGF mRNA expression levels in 30 HG-SOC human specimens normalized for CYPA mRNA expression were analyzed for their correlation: a EDNRA and CTGF correlation, b EDNRA and CCNA correlation. c YAP, ET A R, and ET-1 expression was evaluated by IB analysis of 21 HG-SOC human specimens and six normal ovarian tissues. Tubulin was used as loading control. d , e Overall survival (OS) and disease free survival (DFS) of HG-SOC patients with high (z score > 0.5) and low (z score < 0.5) combined expression levels of ET A R, β-arr1 correlated with YAP gene signature ( CTGF , ANKRD1 and CYR61 ) ( p < 0.014 for OS; p < 0.009 for DFS) ( d ). e OS and DFS of HG-SOC patients with high (z score > 0) and low (z score < 0) combined signature of ET A R, β-arr1, and YAP ( p < 0.009 for OS; p < 0.01 for DFS). Survival analyses from TCGA data set were evaluated by Kaplan–Meier method and a log rank test was used to establish the statistical significance of the distance between curves. High and low gene expression values were defined basing on the z-scores of the signals. f Schematic model of ET A R-dependent YAP activation in HG-SOC models. Mechanistically, nuclear β-arr1 binds mutp53/YAP/transcriptional factor complex to regulate target gene expression. In parallel, ET-1 activates RhoA GTPase, actin dynamics and LATS, for YAP nuclear localization in HG-SOC, through a non-canonical β-arr1/Trio pathway. Integrating these important routes, β-arr1 appears as an emerging hub node, which characterizes important properties that control aggressive features of HG-SOC. Blunting ET-1R/β-arr1-mediated signaling by using macitentan may impair mutp53/YAP/transcriptional machinery, inhibiting tumor growth, metastasis, and rewiring HG-SOC to survive to chemotherapy attack
Ihc Analysis Of Yap, Et A R, And Et 1 Protein Expression, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ihc analysis of yap, et a r, and et-1 protein expression/product/Human Protein Atlas
Average 90 stars, based on 1 article reviews
ihc analysis of yap, et a r, and et-1 protein expression - by Bioz Stars, 2026-02
90/100 stars
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ga017 (a yap/taz agonist)  (Pharmatech)
90
Pharmatech ga017 (a yap/taz agonist)
Expression of <t>YAP</t> and ET-1/ET A R as a prognostic signature <t>in</t> <t>HG-SOC</t> patients. a , b Relative EDNRA (ET A R), CCNA , and CTGF mRNA expression levels in 30 HG-SOC human specimens normalized for CYPA mRNA expression were analyzed for their correlation: a EDNRA and CTGF correlation, b EDNRA and CCNA correlation. c YAP, ET A R, and ET-1 expression was evaluated by IB analysis of 21 HG-SOC human specimens and six normal ovarian tissues. Tubulin was used as loading control. d , e Overall survival (OS) and disease free survival (DFS) of HG-SOC patients with high (z score > 0.5) and low (z score < 0.5) combined expression levels of ET A R, β-arr1 correlated with YAP gene signature ( CTGF , ANKRD1 and CYR61 ) ( p < 0.014 for OS; p < 0.009 for DFS) ( d ). e OS and DFS of HG-SOC patients with high (z score > 0) and low (z score < 0) combined signature of ET A R, β-arr1, and YAP ( p < 0.009 for OS; p < 0.01 for DFS). Survival analyses from TCGA data set were evaluated by Kaplan–Meier method and a log rank test was used to establish the statistical significance of the distance between curves. High and low gene expression values were defined basing on the z-scores of the signals. f Schematic model of ET A R-dependent YAP activation in HG-SOC models. Mechanistically, nuclear β-arr1 binds mutp53/YAP/transcriptional factor complex to regulate target gene expression. In parallel, ET-1 activates RhoA GTPase, actin dynamics and LATS, for YAP nuclear localization in HG-SOC, through a non-canonical β-arr1/Trio pathway. Integrating these important routes, β-arr1 appears as an emerging hub node, which characterizes important properties that control aggressive features of HG-SOC. Blunting ET-1R/β-arr1-mediated signaling by using macitentan may impair mutp53/YAP/transcriptional machinery, inhibiting tumor growth, metastasis, and rewiring HG-SOC to survive to chemotherapy attack
Ga017 (A Yap/Taz Agonist), supplied by Pharmatech, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ga017 (a yap/taz agonist)/product/Pharmatech
Average 90 stars, based on 1 article reviews
ga017 (a yap/taz agonist) - by Bioz Stars, 2026-02
90/100 stars
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Image Search Results


Expression of YAP and ET-1/ET A R as a prognostic signature in HG-SOC patients. a , b Relative EDNRA (ET A R), CCNA , and CTGF mRNA expression levels in 30 HG-SOC human specimens normalized for CYPA mRNA expression were analyzed for their correlation: a EDNRA and CTGF correlation, b EDNRA and CCNA correlation. c YAP, ET A R, and ET-1 expression was evaluated by IB analysis of 21 HG-SOC human specimens and six normal ovarian tissues. Tubulin was used as loading control. d , e Overall survival (OS) and disease free survival (DFS) of HG-SOC patients with high (z score > 0.5) and low (z score < 0.5) combined expression levels of ET A R, β-arr1 correlated with YAP gene signature ( CTGF , ANKRD1 and CYR61 ) ( p < 0.014 for OS; p < 0.009 for DFS) ( d ). e OS and DFS of HG-SOC patients with high (z score > 0) and low (z score < 0) combined signature of ET A R, β-arr1, and YAP ( p < 0.009 for OS; p < 0.01 for DFS). Survival analyses from TCGA data set were evaluated by Kaplan–Meier method and a log rank test was used to establish the statistical significance of the distance between curves. High and low gene expression values were defined basing on the z-scores of the signals. f Schematic model of ET A R-dependent YAP activation in HG-SOC models. Mechanistically, nuclear β-arr1 binds mutp53/YAP/transcriptional factor complex to regulate target gene expression. In parallel, ET-1 activates RhoA GTPase, actin dynamics and LATS, for YAP nuclear localization in HG-SOC, through a non-canonical β-arr1/Trio pathway. Integrating these important routes, β-arr1 appears as an emerging hub node, which characterizes important properties that control aggressive features of HG-SOC. Blunting ET-1R/β-arr1-mediated signaling by using macitentan may impair mutp53/YAP/transcriptional machinery, inhibiting tumor growth, metastasis, and rewiring HG-SOC to survive to chemotherapy attack

Journal: Nature Communications

Article Title: β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer

doi: 10.1038/s41467-019-11045-8

Figure Lengend Snippet: Expression of YAP and ET-1/ET A R as a prognostic signature in HG-SOC patients. a , b Relative EDNRA (ET A R), CCNA , and CTGF mRNA expression levels in 30 HG-SOC human specimens normalized for CYPA mRNA expression were analyzed for their correlation: a EDNRA and CTGF correlation, b EDNRA and CCNA correlation. c YAP, ET A R, and ET-1 expression was evaluated by IB analysis of 21 HG-SOC human specimens and six normal ovarian tissues. Tubulin was used as loading control. d , e Overall survival (OS) and disease free survival (DFS) of HG-SOC patients with high (z score > 0.5) and low (z score < 0.5) combined expression levels of ET A R, β-arr1 correlated with YAP gene signature ( CTGF , ANKRD1 and CYR61 ) ( p < 0.014 for OS; p < 0.009 for DFS) ( d ). e OS and DFS of HG-SOC patients with high (z score > 0) and low (z score < 0) combined signature of ET A R, β-arr1, and YAP ( p < 0.009 for OS; p < 0.01 for DFS). Survival analyses from TCGA data set were evaluated by Kaplan–Meier method and a log rank test was used to establish the statistical significance of the distance between curves. High and low gene expression values were defined basing on the z-scores of the signals. f Schematic model of ET A R-dependent YAP activation in HG-SOC models. Mechanistically, nuclear β-arr1 binds mutp53/YAP/transcriptional factor complex to regulate target gene expression. In parallel, ET-1 activates RhoA GTPase, actin dynamics and LATS, for YAP nuclear localization in HG-SOC, through a non-canonical β-arr1/Trio pathway. Integrating these important routes, β-arr1 appears as an emerging hub node, which characterizes important properties that control aggressive features of HG-SOC. Blunting ET-1R/β-arr1-mediated signaling by using macitentan may impair mutp53/YAP/transcriptional machinery, inhibiting tumor growth, metastasis, and rewiring HG-SOC to survive to chemotherapy attack

Article Snippet: IHC analysis of YAP, ET A R, and ET-1 protein expression in HG-SOC tissues and normal tissues was determined from the human protein atlas ( www.proteinatlas.org ) .

Techniques: Expressing, Control, Gene Expression, Activation Assay, Targeted Gene Expression